Emergency Medicine Research Laboratory


Following is a listing of published research and related abstracts:

  • Iqbal SM, Leonard C, Regmi S, De Rantere D, Tailor P, Ren G, Ishida H, SJ. Pang D, Salo P, Vogel HJ, Hart DA, Waterhouse CC, Jay GD, Schmidt TA, Krawetz RJ. Lubricin/Proteoglycan 4 binds to and regulates the activity of Toll-Like Receptors In Vitro. Scientific Reports. 2016 Jan 11;6:118910. [PMID: 26752378] [PMCID: PMC4707532]
  • Karamchedu NP, Tofte JN, Waller KA, Zhang LX, Patel TK and Jay GD. Superficial zone cellularity is deficient in mice lacking lubricin: A stereoscopic analysis. Arthritis Research and Therapy. 2016 Mar 14;18(1):64. [PMID: 26975998]
  • Torres, JR., Jay, GD., Kim, KS, Bothun, GD. Adhesion in Hydrogel Contacts. Royal Society. 2016 May;472(2189):20150892. [PMID: 27279770] [PMCID: PMC4893181]
  • Zhao C, Ozasa Y, Shimura H, Reisdorf R, Thoreson A, Jay G, Moran S, An K, Amado PC. Effects of Lubricant and Autologous bone marrow stromal cell augmentation on Immobilized Flexor Tendon Repairs. Journal of Orthopaedic Research. 2016; 34(1):154-60. [PMID: 26177854] [PMC5166703]
  • Zhang M, Mani SB, He Y, Hall AM, Xu L, Li Y, Zurakowski D, Jay GD, Warman ML. Induced superficial chondrocyte death reduces catabolic cartilage damage in murine posttraumatic osteoarthritis. Journal of Clinical Investigation. 2016 Aug 1;126(8):2893-902. [PMID: 27427985] [PMCID: PMC4966316]
  • Teeple E, Karamchedu NP, Larson K, Zhang L, Badger GJ, Fleming BC, Jay, GD. Arthroscopic Irrigation of the Bovine Stifle Joint Increases Cartilage Surface Friction and Decreases Superficial Zone Lubricin. Journal of Biomechanics. 2016 Sep 6;49(13):3106-3110. [PMID: 27511596] [PMCID: PMC5056145]
  • Choi B, Asselin N, Pettit CC, Dannecker M, Machan JT, Merck DL, Merck LH, Suner S, Williams KA, Jay GD, Kobayashi L. Simulation-based Randomized Comparative Assessment of Out-of-Hospital Cardiac Arrest Resuscitation Bundle Completion by Emergency Medical Service Teams using Standard Life Support or an Experimental Automation-Assisted Approach. Simulation in Healthcare. 2016 Dec;11(6):365-375. [PMID: 27509064]
  • Reesink H, Watts AE, Mohammed HO, Jay GD, Nixon AJ. Lubricin/Proteoglycan 4 Increases in both Experimental and Naturally Occurring Equine Osteoarthritis. Osteoarthritis and Cartilage. 2017 Jan;25(1):128-137. [PMID: 27498214]
  • Lambiase A, Sullivan BD, Schmidt TA, Sullivan DA, Jay GD, Truitt ER, Bruscolini A, Sacchetti M, Mantelli F. A two week, randomized, double-masked, study to evaluate safety and efficacy of Lubricin (150ug/mL) eye drops versus sodium hyaluronate (HA) 0.18% eye drops (Vismed®) in patients with moderate dry eye. Ocular Surface. 2017 Jan;15(1):77-87. [PMID: 27614318]
  • Oh J, Kuan KG, Tiong LU, Trochsler MI, Jay G, Schmidt TA, Barnett H, Maddern GJ. Recombinant human lubricin for prevention of postoperative intra-abdominal adhesions in a rat model. Journal of Surgical Research. 2017 Feb;(208):20-25. [PMID: 27993210]
  • Larson KM, Zhang, L, Elsaid KA, Schmidt TA, Fleming BC, Badger GJ, Jay GD. Reduction of friction by recombinant human proteoglycan 4 in IL-1α stimulated bovine cartilage explants. Journal of Orthopedic Research. 2017 Mar;35(3):580-589. [PMID: 27411036]
  • Zhang XC., Bermudez AM., Reddy PM., Sarpatwari RR., Chheng DB, Mezoian TJ., Schwartz VR., Simmons QJ., Jay GD., Kobayashi L. Interdisciplinary development of an improved emergency department procedural work surface through iterative design and use testing in simulated and clinical environments. Annals of Emergency Medicine. 2017 Mar;69(3):275-283. [PMID: 27856021]
  • Alquraini A, Jamal M, Zhang L, Schmidt TA, Jay GD, Elsaid KA. The autocrine role of proteoglycan-4 (PRG4) in modulating osteoarthritic synoviocyte proliferation and expression of matric degrading enzymes. Arthritis Research and Therapy. 2017 May 8;19(1):89. [PMID: 28482921] [PMCID: PMC5423025]
  • Regmi SC, Samson ML, Heynen M, Jay GD, Sullivan BD, Srinivasan S, Caffery B, Jones L, Schmidt TA. Degradation of Proteoglycan 4 / Lubricin by Cathepsin S: Potential mechanism for diminished ocular surface lubrication in Sjogren's syndrome. Experimental Eye Research. 2017 May 23;161:1-9. [PMID: 28549901]
  • Waller KA., Chin KE., Jay GD., Zhang LX., Teeple E., McAllister S., Badger GD., Schmidt TA., Fleming BD. Intra-articular rhPRG4 mitigates cartilage damage after destabilization of the medial meniscus in the Yucatan minipig. American Journal of Sports Medicine. 2017 Jun;45(7):1512-1521. [PMID: 28129516] [PMCID: PMC5453820]
  • Larson KM, Zhang Z, Jay GD. Early Genetic Restoration of Lubricin Expression in Trangenic Mice Mitigates Chondrocyte Peroxynitrite Release and Caspase-3 Activation. Osteoarthritis and Cartilage. 2017 Jun 1. Doi.org/10.1016/j.joca.2017.05.012 [PMID: 28579418]